Title : Utilization of the E μ - Myc Mouse to Model Heterogeneity of Therapeutic Response Running Title : Mouse model of human lymphoma therapy heterogeneity
نویسندگان
چکیده
Affiliations: 1 Duke Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, North Carolina, USA 2 Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA 3 Cancer Science Institute of Singapore, National University of Singapore, Singapore 4 The Cancer Institute, Japanese Foundation of Cancer Research, Tokyo, Japan 5 Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA 6 Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA 7 Durham Veterans Affairs Medical Center, Durham, North Carolina, USA * co-first authors
منابع مشابه
Companion Diagnostics and Cancer Biomarkers Utilization of the El-Myc Mouse to Model Heterogeneity of Therapeutic Response
Human aggressive B-cell non-Hodgkin lymphomas (NHL) encompass the continuum between Burkitt lymphoma and diffuse large B-cell lymphoma (DLBCL), and display considerable clinical and biologic heterogeneity, most notably related to therapy response. We previously showed that lymphomas arising in the Em-Myc transgenic mouse are heterogeneous, mirroring genomic differences between Burkitt lymphoma ...
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The Emu-myc transgenic mouse has provided a valuable model for the study of B-cell lymphoma. Making use of gene expression analysis and, in particular, expression signatures of cell signaling pathway activation, we now show that several forms of B lymphoma can be identified in the Emu-myc mice associated with time of tumor onset. Furthermore, one form of Emu-myc tumor with pre-B character is sh...
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The EM-myc transgenic mouse has provided a valuable model for the study of B-cell lymphoma. Making use of gene expression analysis and, in particular, expression signatures of cell signaling pathway activation, we now show that several forms of B lymphoma can be identified in the EM-myc mice associated with time of tumor onset. Furthermore, one form of EM-myc tumor with pre-B character is shown...
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تاریخ انتشار 2014